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KMID : 0352219950170020649
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Kyung Hee Dental Journal
1995 Volume.17 No. 2 p.649 ~ p.659
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ELECTROPHYSIOLOGICAL STUDY OF EFFECT OF RILUZOLE ON THE SODIUM CHANNELS IN THE BOVINE ADRENAL CHROMAFFIN CELL
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Abstract
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Riluzole(2-amino-6-trifluoromethoxy-benzothiazole, RP 54274) has antiglutamatergic effect that possibly: modifies the course of amyotrophic lateral sclerosis (ALS). The purposes of this experiment are to evaluate the effect of riluzole on the sodium channels in bovine adrenal chromaffin cells and to propose a mechanism of pathogenesis of ALS. We recorded and analyzed the sodium currents and sodium conductance of bovine adrenal chromaffin cells in the presence of riluzole by using whole-cell patch clamp technique.
The results ,are: as .follows ;
1. INa.max was recorded at a voltage of 0 or 10 mV.
2. Riluzole inhibited sodium currents of bovine adrenal chromaffin cells.
3. There was a dose-dependent-manner in the inhibiting rate of riluzole tested on sodium current..
4. No noticeable effect of riluzole was observed on the shape and the position along the voltage axis of the peak Na conductance/voltage relationship.
Inhibitory effect of riluzole on sodium current is strongly related with the therapeutic effect of riluzole in ALS.
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